The altered network complexity of resting-state functional brain activity in schizophrenia and bipolar disorder patients

Altered resting state complexity in schizophrenia

The complexity of the human brain's activity and connectivity varies over temporal scales and is altered in disease states such as schizophrenia. Using a multi-level analysis of spontaneous low-frequency fMRI data stretching from the activity of individual brain regions to the coordinated connectivity pattern of the whole brain, we investigate the role of brain signal complexity in schizophreni...

Altered baseline brain activity in children with bipolar disorder during mania state: a resting-state study

BACKGROUND Previous functional magnetic resonance imaging (fMRI) studies have shown abnormal functional connectivity in regions involved in emotion processing and regulation in pediatric bipolar disorder (PBD). Recent studies indicate, however, that task-dependent neural changes only represent a small fraction of the brain's total activity. How the brain allocates the majority of its resources ...

Abnormal brain connectivity in schizophrenia and bipolar disorder – a resting state functional MRI study

Altered Functional Connectivity between Emotional and Cognitive Resting State Networks in Euthymic Bipolar I Disorder Patients

Bipolar disorder is characterized by a functional imbalance between hyperactive ventral/limbic areas and hypoactive dorsal/cognitive brain regions potentially contributing to affective and cognitive symptoms. Resting-state studies in bipolar disorder have identified abnormal functional connectivity between these brain regions. However, most of these studies used a seed-based approach, thus rest...

Resting-state fMRI connectivity impairment in schizophrenia and bipolar disorder.

BACKGROUND Schizophrenia and bipolar disorder share aspects of phenomenology and neurobiology and thus may represent a continuum of disease. Few studies have compared connectivity across the brain in these disorders or investigated their functional correlates. METHODS We used resting-state functional magnetic resonance imaging to evaluate global and regional connectivity in 32 healthy control...